In some cases, a patient already receiving therapy with WELLBUTRIN SR may require urgent treatment with linezolid or intravenous methylene blue. In a patient who requires more urgent treatment of a psychiatric condition, non-pharmacological interventions, including hospitalization, should be considered. Drug interactions can increase the risk of hypertensive reactions.

Use of WELLBUTRIN SR with Reversible MAOIs Such as Linezolid or Methylene Blueĭo not start WELLBUTRIN SR in a patient who is being treated with a reversible MAOI such as linezolid or intravenous methylene blue. Periodically reassess the need for maintenance treatment and the appropriate dose for such treatment. It is unknown whether the dose of WELLBUTRIN SR needed for maintenance treatment is identical to the dose that provided an initial response. It is generally agreed that acute episodes of depression require several months or longer of antidepressant drug treatment beyond the response in the acute episode. To avoid high peak concentrations of bupropion and/or its metabolites, do not exceed 200 mg in any single dose. A maximum of 400 mg/day, given as 200 mg twice daily, may be considered for patients in whom no clinical improvement is noted after several weeks of treatment at 300 mg/day. There should be an interval of at least 8 hours between successive doses. After 3 days of dosing, the dose may be increased to the 300-mg/day target dose, given as 150 mg twice daily. Initiate dosing with 150 mg/day given as a single daily dose in the morning.

The usual adult target dose for WELLBUTRIN SR is 300 mg/day, given as 150 mg twice daily. WELLBUTRIN SR may be taken with or without food.

WELLBUTRIN SR tablets should be swallowed whole and not crushed, divided, or chewed. To minimize the risk of seizure, increase the dose gradually.

Wellbutrin flat affect